The series begins with the return of Upper East Side “It” girl, Serena van der Woodsen (Blake Lively) from a mysterious stay at a boarding school in Cornwall, Connecticut. Blair Waldorf (Leighton Meester), whom creators describe as the queen at the center of their chess game, is a longtime friend and occasional rival of Serena’s, and the Queen Bee of Constance Billard School’s social scene. The story also follows Chuck Bass (Ed Westwick), the bad boy of the Upper East Side; “Golden boy” Nate Archibald (Chace Crawford), Chuck’s best friend and Blair’s ex; and other characters of the turbulent Manhattan scene: Dan Humphrey (Penn Badgley), Nate’s friend and Serena’s on-again, off-again ex; Vanessa Abrams (Jessica Szohr), Dan’s best friend; and Dan’s sister, Jenny Humphrey (Taylor Momsen).

On April 26th 2011, The CW officially renewed Gossip Girl for a fifth season beginning fall 2011